简介:[摘要] 目的:探究阿替普酶对急性脑梗死患者临床疗效及血清炎症因子的影响。方法:选取2022年3月至2023年3月期间于我院收治的急性脑梗死患者82例作为本次研究对象,根据入院先后顺序将所有患者分为治疗组(41例)和对照组(41例)。其中给予对照组患者急性脑梗死替罗非班治疗,治疗组患者则在对照组的基础上采用阿替普酶治疗。对比两组急性脑梗死患者的临床疗效状况。结果:通过对比得出,治疗组患者的总效率高于对照组(P<0.05);2组在治疗后的S-100蛋白β亚基(S-100β)、神经元特异性烯醇化酶(NSE)水平均下降,神经生长因子(NGF)水平升高,且治疗组S-100β、NSE水平均比对照组低(P<0.05);2组在治疗后2周血清炎症因子评分明显低于治疗前(P<0.05)。结论:阿替普酶能有效降低急性脑梗死患者血清NSE和S-100β水平,改善神经功能,并抑制其炎症反应。
简介: 【摘要】 目的 进一步研究干扰素体外释放酶联免疫检验技术在结核病诊断中的优势, 为未来进一步提高结核病检出率奠定基础。方法 138 例患者, 分别接受结核菌素皮肤过敏试验与干扰素体外释放酶联免疫检验。比较两种检查方法诊断结核病的灵敏度、特异度 ; 不同结核病患者干扰素体外释放酶联免疫检验诊断准确率。结果 138 例患者, 病理确诊结核病 42 例, 非结核病 96 例。干扰素体外释放酶联免疫检验诊断结核病的灵敏度为 85.71% ( 36/42 )、特异度为 90.63% ( 87/96 ), 均高于结核菌素皮肤过敏试验的 66.67% ( 28/42 )、 80.21% ( 77/96 ), 差异具有统计学意义( P<0.05 )。肺结核患者 27 例, 肺外结核患者 15 例。肺外结核患者干扰素体外释放酶联免疫检验诊断准确率为 100.00% , 高于肺结核患者的 77.78% , 差异具有统计学意义( P<0.05 )。结论 干扰素体外释放酶联免疫检验方法满足结核病临床诊断的需求, 该诊断方法具有更高的阳性检出率, 并且还具有操作步骤简单、结果精准等优点, 能够减少误诊、漏诊等情况发生, 为结核病的早期预防、早期治疗奠定基础, 因此值得在临床上做进一步推广。 【关键词】 干扰素体外释放酶联免疫检验技术 ; 结核病 ; 结核菌素皮肤过敏试验 [Abstract] objective to further study the advantages of in vitro release of interferon enzyme-linked immunosorbent assay (ELISA) in the diagnosis of tuberculosis and lay a foundation for further improving the detection rate of tuberculosis in the future. Methods 138 patients were tested by tuberculin skin allergy test and interferon releasing enzyme-linked immunosorbent assay. The sensitivity and specificity of the two methods were compared, and the diagnostic accuracy of ELISA for ifn-ifn-release in vitro in different tuberculosis patients was compared. Results of the 138 patients, 42 were confirmed by pathology and 96 were non tuberculosis. The sensitivity and specificity of ELISA were 85.71% (36 / 42) and 90.63% (87 / 96) respectively, which were higher than 66.67% (28 / 42) and 80.21% (77 / 96) of tuberculin skin allergy test. There were 27 cases of tuberculosis and 15 cases of extrapulmonary tuberculosis. The diagnostic accuracy of ELISA was 100.00%, higher than that of 77.78% (P < 0.05). Conclusion the ELISA method of interferon releasing in vitro can meet the needs of clinical diagnosis of tuberculosis. This method has higher positive detection rate, simple operation steps and accurate results, which can reduce misdiagnosis and missed diagnosis and lay a foundation for early prevention and treatment of tuberculosis, Therefore, it is worthy of further promotion in clinical practice.
简介: 【摘要】 目的 观察瑞替普酶溶栓治疗急性ST段抬高型心肌梗死患者的疗效及安全性。方法 将68例急性ST段抬高型心肌梗死患者随机分为两组,瑞替普酶组34例,以瑞替普酶20 mu间隔30 min,分2次静脉推注溶栓;尿激酶组34例,以尿激酶150U,30 min静脉滴注溶栓。比较两组的再通率、出血并发症的发生率及过敏反应。结果 瑞替普酶组的梗死相关动脉总开通率明显高于尿激酶组,有明显差异(PO.05)。结论 瑞替普酶是治疗急性心肌梗死安全有效的溶栓药物。
简介:【摘要】目的:研究急性进展性缺血性脑卒中患者实施替罗非班联合阿替普酶药物治疗的临床有效性。方法:2019年8月—2024年8月中选择80例本院收入的急性进展性缺血性脑卒中患者为调研对象,根据所用疗法,40例阿替普酶单一治疗者划归对照组,40例替罗非班联合阿替普酶治疗者划归观察组,最终比较各组临床有效性。结果:治疗后,观察组神经功能优于对照组,副反应发生率低于对照组,差异显著(P<0.05)。结论:予以急性进展性缺血性脑卒中患者替罗非班联合阿替普酶药物治疗,可加快神经功能恢复速度,避免发生用药后副反应,提高临床有效性,值得推广。