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简介：Objective:Tostudytheeffectofhyperventilationonbraintissueoxygenpressure(PtiO2),braintissuecarbondioxidepressure(PtiCO2),pHvalueandintracranialpressure(ICP)duringintracranialhypertensioninpigs.Methods:Autologousarterialblood(5.5ml±0．5ml)wasinjectedintotheleftfrontallobebymicropumptoestablishthemodelofintracerebralhematomainpigs.Afterbloodinjection,theanimalswerehyperventilatedfor15minutestodecreasethepressureofcarbondioxideinarterialblood(PaCO2)to27.35mmHg±11.97mmHg(1mmHg=0.133kPa).Themeanarterialpressure(MAP),intracranialpressure(ICP),cerebralperfusionpressure(CPP),PtiO2,PtiCO2,pHvalueand[HCO3^-]werecontinuouslymonitoredandthebloodgaswasanalyzed.Results:Afterhyperventilation,theICPsignificantlydecreased(P<0.01),theCPPsignificantlyincreased(P<0.05),whilethePtiO2greatlydecreasedtotheischemiclevel(8.20mmHg±2.50mmHg)(P<0.01),thePtiCO2decreased(P<0.01)andthepHvalueincreased(P<0.01).Atthesametime,bloodgasanalysisshowedthatthePaCO2greatlydecreasedandthepHvalueincreased.Conclusions:HyperventilationcandecreasetheICPandthePtiO2significantly.Therefore,hyperventilationshouldbeavoidedearlyafterbraininjury.ThePtiO2monitoringwillbehelpfulfordetectingcerebralischemiaearly.

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