简介：氨基甲酸酯，硫安类药剂和乙酰胺到的intramolecularorganocatalyticenantioselectiveaza-Michael反应，不饱和的酉同类被开发。这个过程被9-amino-9-deoxy-epi-quinine和diphenyl氢磷酸盐支持与优秀enantioselectivity(92%-97.5%ee)和很好的收益(多达99%)负担得起几综合地有用的五成员、六成员的heterocycles的直接、迅速的合成。

简介：Ithasbeenfoundthatthetwo-phasereactionsofaqueousHCl,HOAcorH3PO4withprimaryamineN1923inchloroformareosiclatingreactions.Theirpower-timecurvesweremeasuredbythetitrationmicrocalorimetricmethod,andtheinductionperiod(tin).Thefirstoscillatingperiod(tp.1)andthesecondoscillatingperiod(tp.2)weredetermined.Theapparentactivatingparametersandtheordersoftheoscillatingsystemswerecalculatedandthefollowingrelationshipswereestablished:fortheoscillatingsystemofhydrochloricacid.

简介：Thecompleteaminoacidsequenceofβ-momorcharin,aribosome-inactivatingproteinfromtheseedsofMomordicacharantiaLinn(Cucurbitaceae)hasbeendetermined.Thishasbeendonebythesequenceanalysisofpeptidesobtainedbyenzymaticdigestionwithtrypsin,chymotrypsinandS.aureusV8protease,aswellasbychemicalcleavagewithBNPS-skatole.Theproteinconsistsof249aminoacidresiduescontainingoneasparagine-linkedsugargroupattachedtothesiteofAsn51andhasacalculatedrelativemolecularmassof28,452Dawithoutadditionofthecarbohydrate.Comparisonofthissequencewiththoseoftrichosanthinandotherribosome-inactivatingproteinsfromdifferentspeciesofplantsshowsasignificanthomologywitheachother.Regardingthesimilarityoftheirbiologicalproperties,anactivedomainoftheseproteinshasbeenpredictedhere.