简介：TheuseoftheLaserMegaJoulefacilitywithintheshockignitionschemehasbeenconsidered.Inthefirstpartofthestudy,one-dimensionalhydrodynamiccalculationswereperformedforaninertialconfinementfusioncapsuleinthecontextoftheshockignitionschemeprovidingtheenergygainandanestimationoftheincreaseofthepeakpowerduetothereductionofthephotonpenetrationexpectedduringthehigh-intensityspikepulse.Inthesecondpart,weconsideredaLaserMegaJouleconfigurationconsistingof176laserbeamsthathavebeengroupedprovidingtwodifferentirradiationschemes.Inthisconfigurationthemaximumavailableenergyandpowerare1.3MJand440TW.Optimizationofthelaser–capsuleparametersthatminimizetheirradiationnon-uniformityduringthefirstfewnsofthefootpulsehasbeenperformed.ThecalculationstakeintoaccountthespecificellipticallaserintensityprofileprovidedattheLaserMegaJouleandtheexpectedbeamuncertainties.Asignificantimprovementoftheilluminationuniformityprovidedbythepolardirectdrivetechniquehasbeendemonstrated.Three-dimensionalhydrodynamiccalculationshavebeenperformedinordertoanalysethemagnitudeoftheazimuthalcomponentoftheirradiationthatisneglectedintwodimensionalhydrodynamicsimulations.

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简介：Theroleofthecoronalelectronplasmatemperatureforshock-ignitionconditionsisanalysedwithrespecttothedominantparametricprocesses:stimulatedBrillouinscattering,stimulatedRamanscattering,two-plasmondecay(TPD),Langmuirdecayinstability(LDI)andcavitation.TPDinstabilityandcavitationaresensitivetotheelectrontemperature.Atthesametimethereflectivityandhigh-energyelectronproductionarestronglyaffected.ForlowplasmatemperaturestheLDIplaysadominantroleintheTPDsaturation.Anunderstandingoflaser–plasmainteractioninthecontextofshockignitionisanimportantissueduetothelocalizationofenergydepositionbycollectiveeffectsandhotelectronproduction.Thisinturncanhaveconsequencesforthecompressionphaseandtheresultinggainfactoroftheimplosionphase.

简介：TodepictthedetailsthatCHOP(C/EBPhomologousprotein)regulatesautophagyandapoptosisinbreastcancercells,theexpressionofCHOPwasinhibitedbytransfectionwithsiRNAsequence.AsshowninFig.1,radiati-Fig.1CHOPinhibitionbysiRNAatmRNAandproteinlevelsafterradiation.onelicitedahigherexpressionofCHOPintheNCgroupcomparedwithcontrol.However,thishigherexpressionwassignificantlyinhibitedinthesiRNAgroup.