简介：

简介：Leukocyterollingandadhesionarecomplexphysiologicalprocessesthathavereceivedagreatdealofattentionoverthepastdecade.Significantincreasesintheknowledgebaserelatedtohowleukocytesadhereinshearflowshaveoccurredasaresultofthedevelopmentofnovelexperimentalandcomputationaltechniques.Micro-andnano-fabricationtechniqueshaveenabledthedevelopmentofnovelflowdevicesforstudyingleukocyteadhesioninsimpleandcomplexgeometries.Improve-mentsincomputertechnologyhaveenabledsimulationsofcomplexflowprocessestobedeveloped.Asaresultofthesead-vancesinknowledgerelatedtoleukocyteadhesion,numerousnoveldeviceshavebeendevelopedthatmimictheleukocyterollingandadhesionprocess.Examplesofthesedevicesincludecellseparationandenrichmentdevicesandtargetedultrasoundcontrastagents.Futureadvancesrelatedtoleukocyterollingandadhesionprocessesholdgreatpromiseforadvancingourknowledgeofdiseaseprocessesaswellasdevelopmentofnoveltherapeuticdevices.