简介:NTrifluoromethyl和cyclopropyl代替了2-isoxazolines与hydroxylamine经由-trifluoromethyl-/-cyclopropyl-substitutedenones的支持DBU的牙齿反应被综合。牙齿反应由迈克尔增加和跟随的环合组成。大量3代用品5-cyclopropyl-5-trifluoromethyl-2-isoxazolines被获得在对在温和反应条件下面的优秀收益好。方法能也适用于另外的代替trifluoromethyl的enones。
Synthesis of trifluoromethyl-/cyclopropyl-substituted 2-isoxazolines by DBU-promoted domino reaction