简介：摘要目的比较不同透析方式对终末期肾病患者血浆胱抑素C(CysC)的清除效果.方法收集１１６例患者透析前和透析后的血浆,用日立７６００－０２０生化分析仪检测血浆中的CysC、尿素氮、肌酐、尿酸的浓度和计算肾小球滤过率,其中７１例采用血液透析(HD)治疗,４５例采用血液透析滤过治疗(HDF).结果HDF组△CysC的均值为(４??２２±１??１７)mg/l,HD组△CysC的均值为(１??２±２??０８)mg/l,两组间比较,t＝－９??９１５,P＜０??０５,差异具有统计学意义.结论CysC可以作为终末期肾病患者透析疗效的评价指标.终末期肾病患者采用HDF法透析疗效显著优于HD法,值得临床上推广和应用.关键词血浆胱抑素C;血液透析;终末期肾病AbstractObjectiveTocomparetheclearanceeffectofplasmacystatinCinpatientswithend－stagerenaldiseaseduringdiffentdialysismodalities??MethodsPlasmawerecollectedfrom１１６patientsbeforeandafterdialy－sis??UsingHitachi７６００－０２０BiochemicalAnalyzermeasuretheconcentra－tionsofCysC、BUN、CREA、UAandGFR??ApplyingHDdialysisto７１patientsand４５casesweretreatedbyHDF??ResultsTheaverageschan－geofCysCinHDFgroupis(４??２２±１??１７)mg/l,andTheaverageschangeofCysCinHDgroupis(１??２±２??０８)mg/l,Comparingbetweenthetwogrou－ps,t＝－９??９１５,P＜０??０５,Thedifferenceisstatisticallysignificant??ConclusionCystatinCcanbeusedasancurativeeffectevaluationindexinpatientswithend－stagerenaldiseasewhoneeddialysis??TheeffectofPatientswi－thend－stagerenaldiseasebyusingHDFdialysisissignificantlybettert－hanthemethodofHD,whichshouldbeclinicallyrecommendedandapK－eypliweodr??dsPlasmaCystatinC;Hemofiltration;End－stagerenaldisease中图分类号R５４１．４文献标识码B文章编号１００８－６３１５(２０１５)１２－０９０６－０２