简介：　　【摘要】目的：本文主要对急性酒精中毒后出现胃粘膜损伤的患者在治疗中应用泮托拉唑治療取得的效果展开探究，了解泮托拉唑对疗效产生的影响。方法：研究的对象为本院 2019年 1月 -2019年 12月期间接受治疗的急性酒精中毒后出现胃粘膜损伤的患者（例数 =50），经回顾性方式对患者展开分组纳入，对照组（例数 =25）在诊疗期间进行西咪替丁治疗，研究组（例数 =25）在诊疗期间接受泮托拉唑治疗，对 2组取得的治疗效果展开组间的分析。结果：研究组经泮托拉唑治疗后总有效率与对照组有差异，两组关于数据差异有统计学意义（ P值范围 <0.05）。结论：单一的应用西咪替丁、泮托拉唑治疗在急性酒精中毒治疗中，均可有效改善患者疗效。但相比于单一的西咪替丁治疗，急性酒精中毒患者采用泮托拉唑治疗可有效改善患者的疗效，可值得推广。  　　【关键词】泮托拉唑 ;急性酒精中毒 ;西咪替丁 ;胃粘膜损伤  　 [Abstract] Objective: To explore the effect of pantoprazole in the treatment of patients with gastric mucosal injury after acute alcoholism, and to understand the effect of pantoprazole on the curative effect. Methods: Patients with gastric mucosal injury after acute alcoholism treated in our hospital from January 2019 to December 2019 (cases = 50) were enrolled in the study. The patients in the control group (cases = 25) were treated with cimetidine during the diagnosis and treatment, and the patients in the study group (cases = 25) were treated with pantoprazole during the diagnosis and treatment The results were analyzed between groups. Results: after pantoprazole treatment, the total effective rate of the study group was significantly different from that of the control group, and the difference between the two groups was statistically significant (P < 0.05). Conclusion: single application of cimetidine and pantoprazole in the treatment of acute alcoholism can effectively improve the curative effect of patients. However, compared with cimetidine alone, pantoprazole can effectively improve the efficacy of patients with acute alcoholism, which is worthy of promotion.