简介：Objective:ToanalyzemoleculartrendsoftheHIVepidemicinShenzhen.Methods:SerumcollectedfromShenzhenAIDSpatientsbetween1992-1999wasanalyzedusingmoleculartechniques.DNAfragmentsoftheHIV-1EnvgenewereamplifiedbynestedPCRfromunculturedperipheralbloodmononuclearcells(PBMCs)fromtheseserumsamples.TheC2-C3regionoftheEnvgenewassequencedandanalyzed.Specifichigh-riskbehaviorswerealsoanalyzed.Results:WefoundthatthetransmissionofHIVinthecitywasmainlythroughsexualbehaviors(46.0%).TherewerefourHIV-1subtypes:B′,B,CandEwith6.31%,7.95%,3.09%and8.92%genedivergenceinsideeachsubtypeinShenzhen.Theseresultssuggestedthatepidemictimeswere6,8,3and9respectively.ThemainepidemicsubtypeswereEandBstrains.AIDSpatient''''''''santigenicvariationwasslightlyhigherthanthatofHIVinfectedindividuals.Conclusion:SurveillancedatareflecttrendsandtheepidemictimeofHIV,whichwillbeusefulforpolicymakerstoformulateeffectivestrategiesofHIV/AIDSpreventionandcontrolinShenzhen.

简介：Objective:TomakeasummaryofthetrendsofHIV/AIDSepidemicandrouteoftransmissioninShenzhenfrom1992to2000toprovidescientificevidenceforthepolicy-makertoformulatestrategiesofHIV/AIDSpreventionandcontrolinShenzhen.Method:ToanalyzeHIV/AIDSsurveillancedatainShenzhenfrom1992to2000bysoftwareEpi-Info.Results:OnehundredandtwoHIVpositivecasesincluding18AIDScases(threecasesdeceased)wereidentifiedinShenzhenfrom1992to2000.Amongthe102cases,thoseinfectedviasexwere46.0%,intravenousdruguse42.9%.Blooddonation7.8%,bloodtransfusionrecipient3.9%,andindeterminate2%.Conclusion:InShenzhen,HIV/AIDSinfectionisspreadingandincreasingrapidly.EffectivepreventionmeasuresmustbetakentoreducetheHIVprevalenceassoonaspossible.