简介：　　 [ 摘要 ] 目的 研究分析慢性阻塞性肺疾病急性加重期（ AECOPD ）臨床治疗中盐酸氨溴索注射液与雾化吸入疗法联合应用的效果。方法 方便选择该院于 2018 年 1 月— 2019 年 6 月期间收治的 83 例 AECOPD 的住院患者为研究对象，以患者床位号的奇偶性以及个人意愿为参考，划分为实验组（ 42 例患者）与对照组（ 41 例患者），对照组患者在常规综合治疗基础上接受盐酸氨溴索注射液 30 mg 静脉输注， 2 次 /d 治疗，观察组患者以对照组患者的治疗方案为基础，同时接受吸入性布地奈德混悬液 2 mg+ 吸入性异丙托溴铵溶液 500 vg 雾化吸入， 2 次 /d 治疗疗法，比对两组患者治疗后的动脉血气分析、肺部啰音消失时间、症状改善时间等因素，以评价临床治疗效果。结果 实验组患者治疗后的动脉血气分析与对照组患者比较，组间差异有统计学意义（ t=13.451 、 3.506 、 8.917 ， P<0.05 ） ; 实验组患者的肺部啰音消失时间为（ 5.11±1.03 ） d ，症状改善时间为（ 6.27±1.37 ） d; 对照组患者的肺部啰音消失时间为（ 7.55±2.21 ） d ，症状改善时间为（ 8.39±2.30 ） d ，数据比对，组间差异有统计学意义（ t=9.052 、 7.159 ， P<0.05 ） ; 实验组患者的治疗有效率为 93.90% ，高于对照组患者的 80.25% ，数据组间比较分析，差异有统计学意义（ χ2=6.648 ， P<0.05 ）。结论 急性加重期慢阻肺患者临床治疗中，对患者联合施以盐酸氨溴索注射液与雾化吸入疗法，可以在短时间内缓解患者症状，进而优化患者的治疗效果，临床应做推广使用。 　　 [ 关键词 ] 急性加重期慢阻肺 ; 盐酸氨溴索 ; 雾化吸入 ; 布地奈德 ; 胺碘酮 [Abstract] Objective To study and analyze the effect of ambroxol hydrochloride injection combined with atomization inhalation therapy in clinical treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods 83 patients with AECOPD admitted to our hospital from January 2018 to June 2019 were conveniently selected as the research object, and were divided into experimental group (42 patients) and control group (41 patients) according to the parity of patient bed number and personal wishes. The patients in the control group received ambroxol hydrochloride injection 30 mg intravenous infusion on the basis of conventional comprehensive treatment, twice /d treatment. The patients in the observation group were treated with inhalation of budesonide suspension 2 mg+ inhalation of ipratropium bromide solution 500 vg and twice /d therapy based on the treatment plan of the patients in the control group. The arterial blood gas analysis, lung rales disappearance time, symptom improvement time and other factors after treatment were compared between the two groups to evaluate the clinical treatment effect. Results Compared with the control group, the arterial blood gas analysis of the experimental group patients after treatment showed statistically significant differences (t=13.451, 3.506, 8.917, P<0.05). The disappearance time of pulmonary rales was (5.11 1.03) d and the improvement time of symptoms was (6.27 1.37) d in the experimental group. The disappearance time of pulmonary rales in the control group was (7.55 2.21) d, and the improvement time of symptoms was (8.39 2.30) d. the data comparison showed that the differences between the groups were statistically significant (t=9.052, 7.159, P<0.05). The treatment effective rate of the patients in the experimental group was 93.90%, which was higher than that of the patients in the control group (80.25%), and the difference was statistically significant (χ2=6.648, P<0.05). Conclusion In the clinical treatment of COPD patients with acute exacerbation, ambroxol hydrochloride injection combined with atomization inhalation therapy can relieve the symptoms of patients in a short period of time, thus optimizing the treatment effect of patients. It should be popularized and used clinically.