简介：　　 [摘要 ]目的 对右美托咪定联合舒芬太尼在全麻患者术后镇痛中的应用效果进行观察。方法 选取 2017年 9月～ 2019年 8月我院收治的 104例全麻手术患者作为研究对象，按照随机数字表法将其分为研究组和对比组，每组各 52例。对比组患者使用舒芬太尼进行镇痛，研究组患者使用右美托咪定联合舒芬太尼进行镇痛。对比分析两组患者的 Ramsay镇静评分、 VAS评分、切口疼痛面积及不良反应发生率。结果 两组患者各时间段的 Ramsay镇静评分比较，差异无统计学意义（ P>0.05）。术后 30 min、 3 h、 48 h，研究组患者的 VAS评分均低于对比组，差异有统计学意义（ P<0.05）。术后 30 min、 3 h、 48 h，研究组患者的术后切口疼痛面积均小于对比组，差异有统计学意义（ P<0.05）。研究组患者的不良反应发生率为 7.69%，对比组患者的不良反应发生率为 11.53%。两组患者的不良反应发生率比较，差异无统计学意义（ P>0.05）。结论 全麻患者术后镇痛中使用右美托咪定联合舒芬太尼的效果更好，起到有效减轻疼痛评分、较小切口疼痛面积效果，应在临床实践中予以广泛推广并使用。  　　 [关键词 ]右美托咪定；舒芬太尼；全麻患者；术后镇痛  　 [Abstract] Objective To observe the effect of dexmedetomidine combined with sufentanil in postoperative analgesia of patients under general anesthesia. Methods 104 patients with general anesthesia who were admitted to our hospital from September 2017 to August 2019 were selected as the subjects of study. According to the method of random number table, they were divided into study group and control group, 52 cases in each group. The control group used sufentanil for analgesia, and the study group used dexmedetomidine combined with sufentanil for analgesia. Ramsay Sedation score, VAS score, incision pain area and adverse reactions were compared between the two groups. Results there was no significant difference in Ramsay Sedation scores between the two groups (P > 0.05). 30 min, 3 h, 48 h after operation, the VAS score of the study group was lower than that of the control group, the difference was statistically significant (P < 0.05). At 30, 3 and 48 hours after operation, the area of incision pain in the study group was smaller than that in the control group (P < 0.05). The incidence of adverse reactions was 7.69% in the study group and 11.53% in the control group. There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion the effect of dexmedetomidine combined with sufentanil in postoperative analgesia of general anesthesia patients is better, which can effectively reduce pain score and small incision pain area. It should be widely used in clinical practice.