摘要
Diabetesmellitus(DM)isachronicsystemicdiseasecharacterizedbyhyperglycemia,withvariouspatho-genicmechanisms.Fromabsoluteorrelativeinsulindeficiency,patientswithDMoftendemonstratevari-ouslevelsofmetabolicdisorders.MajorclinicalmanifestationsofDMincludemetabolicdisorders,vascu-larlesions,circulatorydisturbancesandneurologiccomplications.AlongwithadvancesinDMresearch,re-portsofDMrelatedtinnitusandhearingimpairmenthaveincreasedcontinuously.ResearchonDMrelatedauditorysystemdysfunctionhasfocusedoncochlearmicrocirculation,cellularhomeostasis,geneticsandag-ing.Cochlearmicrocirculationplaysanimportantroleincochlearphysiologyanditsdisordersareassociat-edwithmanyinnereardiseases.Ischemiaandsubsequentreperfusionseenincochlearmicrocirculationdis-ordersareimportantfactorsinhearingdamage.UnderstandingcochlearmicrocirculationandstructuralaswellasfunctionalchangesinDMpatientswithhearinglossandtheircausalfactorswillhelprevealpatho-genicmechanismsindiabetichearinglossandprovidenewideasindevelopinginterventionsandpreventingdamagescausedbydiabetes.
出版日期
2013年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
