摘要
【摘要】 目的：研究并探讨甲基强的松龙注射液和硫酸镁注射液治疗重症支气管哮喘的效果。方法：此次研究的对象是选取笔者所在医院 2012年 1月 -2015年 5月收治的 100例重症支气管哮喘患者，将其临床资料进行回顾性分析，并按照随机原则将全部患者分成对照组和试验组，每组 50例。在常规治疗基础上，对照组患者采用甲基强的松龙注射液治疗，试验组患者给予甲基强的松龙注射液联合硫酸镁注射液治疗。对两组的临床疗效、治疗前后的用力肺活量（ FVC）、 1秒用力呼气量（ FEV1）和最大呼气流量（ PEF）变化情况进行观察分析。结果：试验组患者和对照组患者的临床治疗总有效率分别为 90.0%（ 45/50）、 74.0%（ 37/50），差异有统计学意义（ P<0.05）；治疗后两组患者的肺功能指标 FVC、 FEV1、 PEF均优于治疗前，且试验组患者的肺功能指标 FVC、 FEV1、 PEF优于对照组患者，差异均有统计学意义（ P<0.05）。结论：甲基强的松龙注射液联合硫酸镁注射液治疗重症支气管哮喘具有比较显著的临床效果，可有效改善患者的肺功能，值得临床推广应用。
【关键词】 甲基强的松龙注射液； 硫酸镁注射液； 重症支气管哮喘； 临床效果
Objective: To study and discuss the effect of methylprednisolone injection and Magnesium Sulfate Injection on severe bronchial asthma. Methods: the object of this study was to select 100 cases of severe bronchial asthma admitted to the hospital of my hospital in May -2015 January 2012. The clinical data were analyzed retrospectively, and the patients were divided into the control group and the experimental group according to the random principle, with 50 cases in each group. On the basis of routine treatment, the patients in the control group were treated with methylprednisolone injection, and the patients in the experimental group were treated with methylprednisolone injection combined with Magnesium Sulfate Injection. The clinical efficacy of the two groups, the forced expiratory volume (FVC), 1 second forced expiratory volume (FEV1) and the maximum expiratory flow (PEF) before and after treatment were observed and analyzed. Results: the total effective rate of clinical treatment in the experimental group and the control group was 90% (45/50) and 74% (37/50) respectively. The difference was statistically significant (P<0.05). The pulmonary function indexes of the two groups were superior to those before the treatment, and the pulmonary function indexes of the patients in the experimental group were better than those of the control group, FVC, FEV1, and PEF were superior to the control group. The difference was statistically significant (P<0.05). Conclusion: methylprednisolone injection combined with Magnesium Sulfate Injection has significant clinical effect in the treatment of severe bronchial asthma. It can effectively improve the lung function of the patients and is worthy of clinical application.
出版日期
2019年12月17日（中国期刊网平台首次上网日期，不代表论文的发表时间）
