摘要
Objective:Toobservetheeffectofoctyl-a-cyanoacrylateuponbonehealinganditsdegradationinvitroaftermiddletibialtransversefractureinrabbits,andtoestablishtreatmentofhigherefficacywiththeapplicationofoctyl-a-cyanoacrylate.Methods:MiddletibialtransversefracturemodelofNewZealandrabbitswasestablished.Intheexperimentalgroup,internalfixationwith2mmKirschnerwireswasperformedandthebrokenendswerefixedwithoctyl-a-cyanoacrylate.Inthecontrolgroup,onlyinternalfixationwith2mmKirschnerwireswasconducted.Animalswerekilledatpresettimeintervalsof2,4,6,8,10and12weekspostoperativelyandsampleswereharvested.Results:Twoweeksafteroperation,clearfracturelineswereobservedinboththeexperimentalandthecontrolgroups.Fibroussofttissueconnectionwasnotedbetweenthebrokenendsandtherewassofttissueadhesionaroundthefracturesite.Therewasnocallusformationandthebrokenendsweresurroundedbyadhesivesofttissues.Obviousexternalcallusformationwasconfirmedat8weeksafteroperationinbothgroupswithpartialdisappearanceoffracturelines.Tenandtwelveweeksaftertheoperation,fracturelinesdisappearedcompletelyandtherewasobviousexternalcallusformationandboneunion.Inthefourthweek,fibrouscellsandchondrocyteswerefoundtogrowintothecolloidandsurrounditatthe6thweek.Theadhesivematerialwasdegradedandgraduallyabsorbedatthe8thweek.Chondrificationwasobserved.Conclusions:Twoweeksafterfixationfortibialfractureinrabbits,octyl-a-cyanoacrylatebeginsinvivodegradation.Chondrocytesandfibrocytesgraduallygrowintothedegradationareaandsurroundtheadhesivematerial,whichbrokeintopiecesat8weeks.Completedegradationanddisappearanceoftheadhesivematerialispresentbetween10and12weeks.Nobarriereffecthamperingfracturehealingisnoted.
出版日期
2005年04月14日（中国期刊网平台首次上网日期，不代表论文的发表时间）
