Apoptosis and hormonal milieu in ductal system of normal prostate and benign prostatic hyperplasia-中国期刊网

摘要 Aim:Tostudytheapoptoticrate(AR)andtheandrogenandestrogenmilieuintheproximalanddistalductalsystemsofprostate,inordertohelpexploringtheeffectsofthesefactorsonprostaticgrowthandthepathogenesisofbenignprostatichypertrophy(BPH).Methods:Theproximalanddistalendsoftheductalsystemwereincisedfrom20normalprostateaswellasthehypertrophicprostatetissuefrom20patientswithBPH.TheARwasdeterminedbytheDNAend-labelingmethodanddihydrotestosterone(DHT)andestrodiol(E2),byradioimmunoassay.Results:TherewasnosignificantdifferenceinDHTandE2densitybetweentheproximalanddistalendsoftheductalsystemsinnormalprostate.E2appearedtobehigherinBPHthaninnormalprostatictissues,butthedifferencewasstatisticallyinsignificant.Innormalprostatictissue,theARwassignificantlyhigherinthedistalthanintheproximalendsoftheductalsystem(P＜0.05),whiletheARoftheproximalendswassignificantlyhigher(P＜0.01)thanthatintheBPHtissue.NosignificantcorrelationwasnotedbetweentheDHTandE2densityandtheARbothinthenormalprostateandBPHtissues.Conclusion:ThepaperisthefirsttimedescribingadifferenceinARindifferentregionsoftheductalsystemofnormalprostate,whilethehormonalmilieuissimilar,indicatingafunctionalinhomogeneityoftheseregions.AlowARintheproximalduct,whereBPHoriginates,andanevenlowerARintheBPHtissue,suggestingtheparticipationofapoptosisintheBPHpathogenesis.

1Fa-Xian Yi Qiang Wei Hong Li Xiang Li Ming Shi Qiang Dong Yu-Ru Yang. Risk factors for prostatic inflammation extent and infection in benign prostatic hyperplasia.泌尿科学,2006-05.
2Seung Hwan Lee;Cheol Young Oh;Kyung Kgi Park;Mutt Su Chung;Se Jeong Yoo;Byung Ha Chung. Comparison of the clinical efficacy of medical treatment of symptomatic benign prostatic hyperplasia between normal and obese patients.泌尿科学,2011-05.
3WANG Yu-Rong;XU Yuan;JIANG Zhen-Zhou;ZHANG Lu-Yong;WANG Tao. Triptolide reduces prostate size and androgen level on testosterone-induced benign prostatic hyperplasia in Sprague Dawley rats.中药学,2017-05.
4. Dietary Patterns, Supplement Use, and the Risk of Benign Prostatic Hyperplasia.中医学,2009-04.
5Qin-Song Zeng;Yong-Bin Zhao;Bang-Qi Wang;Min Ying;Wei-Lie Hu. Vlinimally invasive simple prostatectomy for a case ）f giant benign prostatic hyperplasia.泌尿科学,2017-06.
6Koo Han Yoo;Su Kang Kim;Joo-Ho Chung;Sung-Goo Chang. Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia.泌尿科学,2010-05.
7. Benign Prostatic Hyperplasia and Male Lower Urinary Tract Symptoms： Epidemiology and Risk Factors.中医学,2011-04.
8Qin-Song Zeng;Chuan-Liang Xu;Zhi-Yong Liu;Hui-Qing Wang;Bo Yang;Wei-Dong Xu;Tai-Le Jin;Cheng-Yao Wu;Gang Huang;Zheng Li;Bo Wang;Ying-Hao Sun. Relationship between serum sex hormones levels and degree of benign prostate hyperplasia in Chinese aging men.泌尿科学,2012-05.
9Huan-Tao Zong;Xiao-Xia Peng;Chen-Chen Yang;Yong Zhang. A systematic review of the effects and mechanisms of preoperative 5α-reductase inhibitors on intraoperative haemorrhage during surgery for benign prostatic hyperplasia.泌尿科学,2011-06.
10李丽会;张淑静;徐名一. Clinical Progress on Acupuncture Treatment of Prostatic Hyperplasia.中医学,2009-04.

Apoptosis and hormonal milieu in ductal system of normal prostate and benign prostatic hyperplasia

来源期刊

相关推荐

同分类资源更多

相关关键词

Apoptosis and hormonal milieu in ductal system of normal prostate and benign prostatic hyperplasia

来源期刊

相关推荐

同分类资源 更多

相关关键词

同分类资源更多