The Effect of Electric Properties of Liposomes on SOD-like Activity ofCopper Salicylate

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摘要 TheSOD-likeactivitiesofcoppersalicylateencapsulatedinneutralpositivelyandnegativelychargedliposomeswerestudiedwithcytochromecmethod.TheresultsshowedthattheSOD-likeactivityofcoppersalicylateencapsulatedinneutralliposomeswasenhancedover3timesmorethanthatofcoppersalicylateinaqueoussolution.However,theactivitydecreasedforcoppersalicylateencapsulatedinpositivelyandnegativelychargedliposomes.Itwasalsofoundthatatexperimentalconcentrationstherewasnoregularityforthechangeofactivityofcoppersalicylateencapsulatedinnegativelychargedliposomes,andcoppersalicylateencapsulatedinliposomeswithmorenegativechargescouldpromotethedismutationofsuperoxideanionfreeradicals,however,socouldcoppersalicylateencapsulatedinliposomeswithfewernegativechargesonlyinlowerconcentrations.
机构地区 不详
出处 《中国药学:英文版》 2001年2期
出版日期 2001年02月12日(中国期刊网平台首次上网日期,不代表论文的发表时间)
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