PRL-3在胃癌中的表达及临床意义

PRL-3 胃癌 免疫组化中图分类号R2 文献标号A 文章编号1671-8725（2014）11-0006-02Expressions of PRL-3 in gastric carcinoma and their clinical significanceLiang jie li rui-guang Wang Hai-jiang（Endoscopy center The third Affiliated Hospital of Xinjiang Medical University Urumqi 830011 China)abstractObjective To investigate the significance of PRL-3 in the occurrence of gastric cancer and its correlation with the clinical manifestations.Methods PRL-3 expression was determined in 80 cases of gastric cancer by PV-9000 immunohistochemistry. Primary cancer tissue and para-carcinomatissue over 5 cm away from primary cancer were sampled for each case. None of these patients had received anti-cancer treatment previously.Resultsgastric cancer tissue has higher positive rate of PRL-3 expression than para-carcinoma tissue (P< 0.05) and expression level of PRL-3 is correlated withdepth of invasion lymph node metastasis and TNM staging (P< 0.05 for all).Conclusions expression of PRL-3 is closely correlated with invasion