Study on Functional Connectivity Density in Patients with Frontal Lobe Tumor at Resting-State-中国期刊网

摘要 Atpresent,theneuropathologicalmechanismsandtheplasticchangesofbraincognitivefunctioninpatentswithfrontlobetumorremainunclear,moststudiesjustfocusedonglobalmeasuresofbrainfunctionalconnectivitywithoutconsideringthetimecorrelationinthedifferentregionsofthebrain.Thisstudyaimstoinvestigatebraincognitivealterationsandfunctionalplasticityinpatientswithfrontlobetumoratresting-statebyconductingfunctionalconnectivitydensity(FCD)mappingandgrangercausalityanalysis(GCA).Firstly,FCDmappingwasusedtoextractabnormalfunctionalconnectivity(FC)ofpatientswithfrontallobetumor,andanalyzedalteredbrainFCinbothshort-andlong-rangeFCD.Then,thevoxel-wiseGCAmethodwasusedtoanalyzethecausalrelationshipbetweenalteredFCregionsandotherregionsinordertodetectthetimecorrelationbetweenregionsofinterest(ROI)andrevealthedirectionofinformationflowbetweenbrainROIs.Itwasfoundthatpatientshadincreasedshort-rangeFCDinmotorandspaceattentionfunctionareas,hadincreasedshort-andlong-rangeFCDsbothinTemporalandInsula,andthecausalcoefficientswerechangedobviouslyinTemporalandFrontal.Theresultsshowthatthereisafunctionalplasticityinspaceattentionfunctionareas.TemporalandInsulaareaffectedbytumorinfrontallobe,andfunctionalreorganizationappearsinsideTemporal.

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Study on Functional Connectivity Density in Patients with Frontal Lobe Tumor at Resting-State

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Study on Functional Connectivity Density in Patients with Frontal Lobe Tumor at Resting-State

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