摘要
Objective:TodiscussthemechanismofcerebralvesselspasmcausedbyconcussionandtheeffectofNimodipineonconcussion.Methods:Atotalof224patientswhoweretreatedfromMarch1995toOctober1999weredividedintotwogroupsrandomly,ie.Nimodipinegroup(113cases)andcontrolgroup(11cases).Middlecerebralartery(MCA),basilarartery(BA)andtheaveragepeakforwardvelocityofcerebralbloodflowwereobservedbycolorthree-dimensionaltranscranialDoppler(3D-TCD)within24hoursafteradmissionandattheendof3-6daysoftreatment.Cerbralbloodflowchanges,characteristicsandtreatmenteffectwereanalyzedanddeterminedbyclinicalmainsymptomdisappearancerate.Results:Inconcussion,cerebralbloodflowwasdividedinto3phases:cerebralbloodflowlowinfusiondilationphase,cerebralbloodvesselspasmphaseandcerebralbloodflowrecoveryphase.IntheNimodipinegroup,clinicalmainsymptomdisappearanceratewashigherthanthatinthecontrolgroupinthecerebralspasmandrecoveryphaseswithasignificantdifference(P<0.01).Conclusions:Cerebralvesselspasm,hypoxiaandischemialesionarethemainpathologicalchanges.Whethercerebraldysfunctionisreversibleornotismainlydeterminedbyspasmtimeofcerebralbloodvessel.Nimodipinehasagoodeffectonreleasingspasmanddiminishingthecerebralbloodfolwvelicity.Itnotonlyimprovescurativeeffectonconcussion,butalsoreducesandpreventsconcussionsequelae.Hence,concussionpatientswhohavecerebralspasmconfirmedby3D-TCDshouldbegivenNimodipineroutinelyandearly.
出版日期
2002年06月16日（中国期刊网平台首次上网日期，不代表论文的发表时间）
