Studies on the Synthesis,the 2D and 3D—QSAR About Lipophilic Antifolate 2,4—Diamino—5—methyl—6—（Substituted Benzylamino）Quinazoline Compounds-中国期刊网

摘要 Methetraxate(MTX),aclassicaldihydrofolatereductaseinhibitor,wasasuccessfulclinicalantitumoragent,havingpotentinhibitoryactivitiestoseveralkindsoftumors.Unfortunately,thecancercellkswereeasiertoproduceresistancetoMTXwhichendedinthefailureofchemotherapy.Inordertoovercometheresistanceoftumorcells,anewkindofdihydrofolatereductaseinhibitorscallednonclassicalantifolateincludingtriazines,pyrimidinesandquinazolinesweredesignedandsynthesized.Becauseofthedifferentantitumormechanismsbetweenthetwokindsofcompunds,thecancercellsresistanttoMTXmaystillbesensitivetothenonclassicalantifolate.Accordingtothistheory,somenonclassicalantifolate2,4-diamino-5-methyl-6-(substitutedbenzylamino)quinazolineswiththegeneralstructureshowninFIg.1weresynthesizedandtheirantitumoractivitiesweredeterminedinthisthesis.

1. Studies on the Synthesis,the 2D and 3D-QSAR About Lipophilic Antifolate 2,4-Diamino-5-methyl-6-(Substituted Benzylamino) Quinazoline Compounds.药学,1997-02.
2王骏波. 2D→3D.教育学,2013-02.
3. 2D如何转制3D.电影电视艺术,2016-01.
4Jiangli XUE;Maosong MO;Zhuming LIU;Dapeng YE;Zhihua CHENG;Tong XU;Liangti QU. A general synthesis strategy for the multifunctional 3D polypyrrole foam of thin 2D nanosheets.材料科学与工程,2018-02.
5. 2D通往3D的捷径 Amorphium.计算机应用技术,2003-07.
6熊芹. 从2D到3D/4D：超声成像技术的飞跃.临床医学,2024-07.
7高晓红. 轻松玩转换，2D电影3D看.计算机软件与理论,2011-02.
8HAO Wuqiang;DONG Lijun. 3D object reconstruction by point coordinates of 2D line drawings.计算机应用技术,2013-01.
9Essam Kh. Ahmed;Mohamed A. Ameen. Synthesis of thiopyrano[4',3':4',5']pyrido[3',2':4, 5]furo[3,2-d]pyrimidines.化学,2010-06.
10Angelo Di Egidio;Daniele Zulli;Alessandro Contento. Comparison between the seismic response of 2D and 3D models of rigid blocks.地震学,2014-01.

Studies on the Synthesis,the 2D and 3D—QSAR About Lipophilic Antifolate 2,4—Diamino—5—methyl—6—（Substituted Benzylamino）Quinazoline Compounds

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Studies on the Synthesis,the 2D and 3D—QSAR About Lipophilic Antifolate 2,4—Diamino—5—methyl—6—（Substituted Benzylamino）Quinazoline Compounds

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