简介：Cancercellsarewelldocumentedtorewiretheirmetabolismandenergyproductionnetworkstosupportandenablerapidproliferation,continuousgrowth,survivalinharshconditions,invasion,metastasis,andresistancetocancertreatments.SinceDr.OttoWarburg’sdiscoveryaboutalteredcancercellmetabolismin1930,thousandsofstudieshaveshedlightonvariousaspectsofcancermetabolismwithacommongoaltofindnewwaysforeffectivelyeliminatingtumorcellsbytargetingtheirenergymetabolism.Thisreviewhighlightstheimportanceofthemainfeaturesofcancermetabolism,summarizesrecentremarkableadvancesinthisfield,andpointsoutthepotentialstotranslatethesescientificfindingsintolife-savingdiagnosisandtherapiestohelpcancerpatients.

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简介：AIM:Todescribetheclinicalfeatures,systemicassociations,treatmentandvisualoutcomesinSaudipatientswithscleritis.·METHODS:AretrospectivechartreviewwasperformedforpatientswithscleritispresentingtotwotertiarycareeyehospitalsinRiyadh,SaudiArabia,from2001to2011.Datawerecollectedontheclinicalfeaturesofscleritis,subtypesofscleritis,associatedsystemicdisease,historyofpreviousocularsurgeryandmedicaltherapy,includingtheuseofimmunosuppressants.Treatmentoutcomeswereevaluatedbasedonbest-correctedvisualacuity(BCVA)andresponsetotreatment.·RESULTS:Ofthe52patientsincludedinthestudy,non-necrotizinganteriorscleritiswasthemostcommontypeofscleritisin22patients(42.3%),followedbyposteriorscleritisin14patients(26.9%).Themajorityofcases,31patients(59.6%),wereidiopathicinnature.Systemicassociationswerepresentin12patients(23.1%).Infectiousscleritiswasconfirmedin6patients(11.5%):3withbacterialscleritisafterpterygiumexcision,2patientswithscleritisrelatedtotuberculosisand1patientwithscleritisresultingfromherpessimplexinfection.Forthevarioussubtypesofscleritis,BCVAvaluesaftertreatmentandtimetoremissionsignificantlydiffered(P<0.05,allcases).Systemicimmunosuppressivetherapiesinadditiontosteroidswereadministeredto46.2%ofallpatients.TheT-signwaspresentonB-scanultrasonographyin9(64.3%)ofthe14posteriorscleritispatients.·CONCLUSION:Non-necrotizinganteriorscleritiswasthemostcommonsubtypeofscleritis.Finalvisualoutcomeandtimetoremissiondifferedamongthevariousscleritissubtypes.

简介：AIMThepreviousworkhasdemonstratedthatthepolysaccharidesofAngelicasinensis(Oliv.)Dielshavesignificantlyantitumoractivityandindicatedthattheactivityisstronglydependentontheirstructures.However,therelationshipsbetweenthestructureandtheactivitiesarestillambiguous.Thus,atpresent,moreeffortsarebeingexpendedinseekingtoisolatethepolysaccharidesfromAngelicasinensis(Oliv.)Diels,measuretheirstructuralfeaturesandantitumoractivities,andelucidatestructure-activityrelationshipsofpolysaccharides.METHODSTherootsofAngelicasinensis(Oliv.)DielswereextractedWithwater,separatedbySephacrylS-400andDEAE-sephadexA-25columnsandfurtherpurifledonSephadexG-100column.

简介：Objective:Toassesstheclinicalfeatures,survivalandprognosticfactorsofprimarytesticulardiffuselargeB-celllymphoma(DLBCL).Methods:Aretrospectivestudyof37patientswithprimarytesticularDLBCLwascarriedoutfromNovember2003toMay2012.Theirclinicalfeatures,survivalandprognosticfactorswereanalyzed.Results:Duringamedianfollow-upperiodof39.8months(5.4-93.0months),themedianprogression-freesurvival(PFS)was26.2months(95%CI:0-65months)andthe3-yearoverallsurvival(OS)ratewas78.4%.Withinthewholecohort,thefactorssignificantlyassociatedwithasuperiorPFSwerelimitedstage(stageI/II),lactatedehydrogenase(LDH)≤245U/L,internationalprognosticindex(IPI)≤1,primarytumordiameter<7.5cm,andpatientswhohadcompleteresponse(CR)andreceiveddoxorubicin-containedchemotherapy(P<0.05).Therewasatrendtowardsuperioroutcomeforpatientswhoreceivedcombinedtherapy(surgery/chemotherapy/radiotherapy)(P=0.055).PatientswhohadCR,primarytumordiameter<7.5cmandIPIscore≤1weresignificantlyassociatedwithlongerPFSatmultivariateanalysis.Conclusions:PrimarytesticularDLBCLhadpoorersurvival.CR,primarytumordiameterandIPIwereindependentprognosticfactors.Thecombinedtherapyoforchectomy,doxorubicin-containedchemotherapyandcontralateraltesticularradiotherapy(RT)seemedtoimprovesurvival.

简介：AbstractBackground:Due to development of magnetic resonance-based functional imaging, it is easier to detect micro-structural alterations of tumor tissues. The aim of this study was to conduct a preliminary evaluation of the correlation of non-Gaussian diffusion kurtosis imaging (DKI) parameters with expression of molecular markers (epidermal growth factor receptor [EGFR]; anaplastic lymphoma kinase [ALK]; Ki-67 protein) in patients with advanced lung adenocarcinoma, using routine diffusion-weighted imaging as the reference standard.Methods:Data from patients with primary lung adenocarcinoma diagnosed at Cancer Hospital, Chinese Academy of Medical Sciences (CHCAMS) from 2016 to 2019 were collected for retrospective analysis. The pathologic and magnetic resonance imaging data of 96 patients who met the inclusion criteria were included in this study. Specifically, the Kapp and Dapp parameters measured from the DKI model; apparent diffusion coefficient (ADC) value from the diffusion-weighted imaging model; and the EGFR, ALK, and Ki-67 biomarkers detected by immunohistochemistry and/or molecular biology techniques after biopsy or surgery were evaluated. The relations between quantitative parameters (ADC, Kapp, Dapp) and pathologic outcomes (EGFR, ALK, and Ki-67 expression) were analyzed by Spearman correlation test.Results:Of the 96 lung adenocarcinoma lesions (from 96 patients), the number of EGFR- and ALK-positive and high Ki-67 expressing lesions were 53, 12, and 83, respectively. The Kapp values were significantly higher among patients with EGFR-positive mutations (0.81 ± 0.12 vs. 0.66 ± 0.10, t = 6.41, P < 0.001), ALK rearrangement-negative (0.76 ± 0.12 vs. 0.60 ± 0.15, t = 4.09, P < 0.001), and high Ki-67 proliferative index (PI) (0.76 ± 0.12 vs. 0.58 ± 0.13, t = 4.88, P < 0.001). The Dapp values were significantly lower among patients with high Ki-67 PI (3.19 ± 0.69 μm2/ms vs. 4.20 ± 0.83 μm2/ms, t = 4.80, P < 0.001) and EGFR-positive mutations (3.11 ± 0.73 μm2/ms vs. 3.59 ± 0.77 μm2/ms, t = 3.12, P = 0.002). The differences in mean Dapp (3.73 ± 1.26 μm2/ms vs. 3.26 ± 0.68 μm2/ms, t = 1.96, P = 0.053) or ADC values ([1.34 ± 0.81] × 10-3 mm2/s vs. [1.33 ± 0.41] × 10-3 mm2/s, t = 0.07, P = 0.941) between the groups with or without ALK rearrangements were not statistically significant. The ADC values were significantly lower among patients with EGFR-positive mutation ([1.19 ± 0.37] × 10-3 mm2/s vs. [1.50 ± 0.53] × 10-3 mm2/s, t = 3.38, P = 0.001) and high Ki-67 PI ([1.28 ± 0.39] × 10-3 mm2/s vs. [1.67 ± 0.77] × 10-3 mm2/s, t = 2.88, P = 0.005). Kapp was strongly positively correlated with EGFR mutations (r = 0.844, P = 0.008), strongly positively correlated with Ki-67 PI (r = 0.882, P = 0.001), and strongly negatively correlated with ALK rearrangements (r = -0.772, P = 0.001). Dapp was moderately correlated with EGFR mutations (r = -0.650, P = 0.024) or Ki-67 PI (r = -0.734, P = 0.012). ADC was moderately correlated with Ki-67 PI (r = -0.679, P = 0.033).Conclusions:The Kapp value of DKI parameters was strongly correlated with different expression of EGFR, ALK, and Ki-67 in advanced lung adenocarcinoma. The results potentially indicate a surrogate measure of the status of different molecular markers assessed by non-invasive imaging tools.

简介：AbstractBackground:The aim of this study was to retrospectively analyze our experience with the patients who underwent surgical treatment of posterior communicating artery (PComA) aneurysms originating from fetal posterior cerebral artery (fPCA) and analyze the risk factors for the postoperative radiological infarction and outcome.Methods:From 2011 to 2020, we retrospectively reviewed 74 PComA aneurysms originating from fPCA in terms of the clinical and radiological features and obtained the follow-up data from the Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University. The relationships between these features and follow-up data were assessed with the univariate and multivariate analysis.Results:In this series, 74 aneurysms were occurring at the origin of fPCAs. All the patients showed complete obliteration of their aneurysms. Full fPCA type tends to be a predictive factor for radiological infarction (univariate χ2 = 5.873, P = 0.027; multivariate OR = 0.264, P = 0.060). Postoperative radiological infarction (univariate χ2 = 12.611, P = 0.001; multivariate OR = 6.033, P = 0.043), rupture (univariate χ2 = 4.514, P = 0.047; multivariate OR = 57.966, P = 0.044), and hypertension (univariate χ2 = 5.301, P = 0.024; multivariate OR = 24.462, P = 0.029) tend to be the independent predictive factors for poor prognosis at 3 months after discharge.Conclusions:In conclusion, we report a series of patients harboring aneurysms originating from the fPCA. Surgical clipping is a reliable strategy. Full fPCA type is related to postsurgical infarction. Postoperative radiological infarction, rupture, and hypertension tend to be the independent predictive factor for poor prognosis at 3 months after discharge.

简介：【摘要】目的：探讨院前急救护理路径在脑卒中患者院前急救中的作用。方法：选择 2016年 9月 -2017年 1月期间呼救中心接收的 260例脑卒中患者，根据呼救先后顺序分为观察组 130例以及对照组患者 130例。对照组脑卒中患者按照常规护理进行救治，观察组脑卒中患者则根据院前急救护理路径进行救治，比较两组患者的治疗结局。结果：观察组脑卒中患者的呼救至救护车到达时间为 24.61±10.14min，对照组脑卒中患者呼救至救护车达到时间为 30.62±14.15min， P＜ 0.05；观察组脑卒中患者入院接受专科治疗时间为 38.68±10.49min，对照组脑卒中患者入院接受专科治疗时间为 46.72±12.49min， P＜ 0.05；观察组脑卒中患者的致残率和致死率分别为 9（ 6.92%）、 5（ 3.85%）较对照组患者 16（ 12.31%）、 13（ 10%）有明显的优势， P＜ 0.05。结论：脑卒中患者采用院前急救护理路径有效的缩短患者获得急救时间间隔，阻止病情的恶化，改善不良治疗结局。

简介：摘要目的研究院前急救护理路径在脑卒中患者院前急救中的应用。方法随机抽取我院2010年2月-2013年4月经急诊科收治的脑卒中患者100例，分为治疗组和常规组，每组各50例。针对常规组采用常规急救护理救治，针对治疗组采用院前急救护理路径救治。结果常规组呼救后到在院前接受救治时间为23.49±12.27min,到医院接受救治的时间41.67±14.71min；治疗组呼救后到在院前接受救治时间为17.61±6.14min,到医院接受救治的时间30.71±12.56min；常规组总死亡伤残比例为74％，治疗组总死亡伤残比例为50％。所有数据均符合统计学差异（P＜0.05）。结论对于脑卒中患者采用院前急救护理路径可以有效的缩短患者发生病情后至接受救治时的时间，降低死亡伤残率，提高救治效果。

简介：摘要：目的 探讨院前急救护理模式在脑卒中患者院前急救中的影响。方法 选取2021.3~2022.3期间我院急诊科接收的50例脑卒中患者，根据来院方式的不同进行分组，对照组由家属送至急诊科，应用常规护理，研究组为120接诊，应用院前急救护理模式，观察两组救治成功率和致残率。结果 救治成功率：研究组更高（P＜0.05）；致残率：研究组更低（P＜0.05）。结论 脑卒中患者应用院前急救护理模式效果显著，可促使救治成功率得到有效提升，并可降低致残率。

简介：【摘要】目的：研究脑卒中患者院前急救中应用院前急救护理路径的效果。方法：根据护理方式的不同将我院2020年1月-2022年6月收治的80例脑卒中患者分为两组，对照组（40例）行常规护理，研究组（40例）行院前急救护理路径干预，观察比较两组护理效果。结果：研究组院前急救各环节所用时间均短于对照组，患者残疾率低于对照组（P0.05）。结论：院前急救护理路径可缩短院前急救时间，降低患者残疾风险。

简介：【摘要】目的：探究院前急救护理路径在脑卒中患者院前急救中的应用效果。方法：回顾性分析100例研究对象临床资料，均为医院2022年1月至2023年12月收治脑卒中患者。依据院前急救护理模式分为常规组（50例，常规院前急救护理干预）与路径组（50例，院前急救护理路径干预），对比护理效果。结果：路径组出诊准备时间、呼救至院前抢救时间、呼救至专科治疗时间短于常规组（P＜0.05），急救总有效率（96.00%）高于常规组（84.00%）（P＜0.05），神经功能缺损评分、肢体运动功能评分、日常活动能力评分、意识障碍评分，低或高于常规组（P＜0.05）。结论：院前急救中为脑卒中患者行院前急救护理路径干预利于急救护理效率提升与效果改善，可在一定程度上减轻疾病发作对身体功能的损伤，降低不良预后。

简介：针对近年来我国时常发生的地震灾害,结合地震中伤员的特点,探讨救援中批量伤员快速分类后送的组织实施方法,为提高此类伤员的综合救治水平提供参考.

简介：摘要目的观察规范药品合理分类对促进医院西药房高效管理的影响，探讨其可行性。方法选择我院西药房规范药品合理分类后（2014年度）作为实验组（S组），未进行规范药品合理分类（2013年度）作为对照组（D组），两组均以国家相关规定及药品说明书等为参考，观察规范药品合理分类前后患者的投诉率及满意度。结果S组患者的满意度（96.04%）明显高于D组（89.0%），S组发生患者投诉率（0.06%）明显少于D组（0.45%）。结论规范药品合理分类，不仅能提高患者的满意度，而且能减少医患纠纷，从而促进药房的高效管理。

简介：摘要目的探究灾害救援中的检伤分类与抢救措施,分析检伤分类在突发灾害中的应用效果.方法２０１１年３月－２０１３年５月我院对８批次６０例伤员进行了院前急救,致伤原因包括交通事故、火灾、多发伤、炸伤、群架斗殴、颅脑外伤、大面积烧伤、腹部闭合性损伤、下肢骨折、软组织损伤等,并对所有伤员均进行了院前急救与后期转运.结果６０例伤员中,现场急救２０例,其中抢救成功与死亡的人数分别为１９例、１例,抢救成功率达到９５．０％(１９/２０).所有伤员中４８例需要尽快救治,其中２例伤员在转运时病情突变,并及时进行抢救,及时抢救率达到１００％;所需经费达到２０００万元.结论当面对突发灾害伤员时,应做好充分的院前急救准备,救援人员达到急救现场后先进行检伤分类,明确患者病情及危重程度,对病情危重的患者第一时间进行抢救治疗,争取最佳的抢救时间.关键词灾害救援;检伤分类;抢救中图分类号R１２９文献标识码B文章编号１００８－６３１５(２０１５)１２－１２６６－０２

简介：摘要中医古籍分类方法标准化可为各类中医古籍藏书单位提供明确和可靠的分类参考依据，推进中医古籍的共享与利用。通过历代中医古籍分类方法的调查研究，对照《中国中医古籍总目》分类表，参考《中华古籍总目》分类表，制定《中医古籍分类标准》。本标准规定了中医古籍分类的三级类目与入类原则，主要由基本大类、三级类目表、入类原则与示例及使用说明等部分组成。

简介：设计意图：我和孩子们捡拾了许多幼儿园里的落叶,打算投放到美工区。这些树叶有的大有的小,有的圆圆的有的尖尖的,有的薄薄的有的厚厚的,孩子们在捡拾的过程中会不自觉地区分。这是让幼儿接触分类统计的有利时机——为此,根据幼儿的关注点和已有能力,我设计了本活动,力求让幼儿感受分类统计在生活中的运用.

简介：2001年7月20日，我国卫生部批准《结核病分类》为中华人民共和国卫生行业标准(WS196-2001)，其内容如下：

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