简介:为了从期刊文献的学科属性实现族性检索,为文章的分类统计创造条件,本刊2005起均对具有文献标识码的文章采用《中国图书馆分类法》(第四版)进行分类后。标识分类号文章一般标识1个分类号,多个主题的文章可标识2个或3个分类号;主分类号排在第一位,多个分类号之间应以分号分隔。希望有条件查询的作者在来稿时自行标明中图分类号。
简介:SyphilisisafocalpointinpreventionandcontrolofSTDs.Syplhilisnowpresentsdifferentepidemiologicalandclinicalfeaturestothepast,andthesyphilisepidemicisnotseriousaspreviously-latesyphilisandcongenitalsyphilisbeingrelativelyrareinthewholecountry.Theclinicalfeaturesofskinlesionsinprimaryandsecondarysyphilishavenotchangedsubstantiallybuttheproportionofvarioustypesoflesionsisdifferenttothepast.AssyphilishasnotbeenpresentinChinaformorethan15years,someyoungmedicalworkershavenoexperienceinthediagnosisandtreatmentofthisdisease.Theyoftenmisdiagnoseormissdiagnosis.Thesemedicalworkersneedbetterknowledgeandtreatmentskills.Inordertocontrolsyphilisassoonaspossiblethroughearlydiagnosisandtreatment,thisarticlegivesanintroductiontothisissueforcolleaguesbywayofacomparisonofthepaststatusandthepresent.
简介:客观:复制错误(RER)与colorectal癌(CRC)的开始和开发有关。调查RER+和RER的不同生物行为?CRC。方法:染色PCR单个的海滨符合构造多型性(PCR-SSCP)和使中毒的polyacrylamide胶化电气泳动方法的银被用来在染色体2上在4loci检测microsatellite不稳定性(MSI),5,17在60colorectal癌(CRC)和他们的配对的正常组织的嵌入石蜡的标本。如果,RER+被获得2或更多的loci作为获得额外的乐队表现了。结果:结果证明RER+在19/60CRC,7个案例在之中有家庭历史被发现。根据阿姆斯特丹的标准,4作为世袭nonpolyposiscolorectal癌症(HNPCC)被诊断,并且哪个3个案例是RER+。在HNPCC(75%)的比率RER+在分散的CRC(28.5%)之中比那显著地高。大多数RER+CRC有糟糕区分的腺癌的特征(P<0.01),包含冒号的右边的趋势(P<0.05),有家庭历史的一个更高的比例(P<0.05),Ducke的A和B阶段(P<0.05)。结论:结果显示RER+是在CRC的一个相对普通的分子的事件。在RER+和RER之间有不同clinico病理学的特征和行为吗?CPC。
简介:AbstractIntroduction:Trichofolliculoma characterized clinically by the presence of acentral dilated pore with tufted hairs and corresponds histologically to a central primary follicle and many secondary vellus hair follicles originating from it. Thus far, dermoscopy description of trichofolliculoma has been lacking.Here, we describe a typical case of trichofolliculoma, particularly the special manifestation under the dermoscopy.Case presentation:A 29-year-old man complained a five-year history of a nodule containing a central whitish hair plug on his left tempus. Dermoscopic examination revealed a well-defined, yellow macule with a central whitish hair plug surrounded by dilated capillaries, and histopathological analysis was consistent with trichofolliculoma.Discussion:The findings of dermoscopy were also vary, which may be affected by the origin of the disease, various phases of the hair cycle, depth of the lesion, and even external stimulus.Conclusion:Diagnosis of trichofolliculoma is sometimes difficult because the presence of the central crater and visible hairs is low, and dermoscopy examination may be a potentially useful diagnostic tool.
简介:AbstractBackground:Anorexia nervosa (AN) is a psychological disorder, which is characterized by the misunderstanding of body image, food restriction, and low body weight. An increasing number of studies have reported that the pathophysiological mechanism of AN might be associated with the dysbiosis of gut microbiota. The purpose of our study was to explore the features of gut microbiota in patients with AN, hoping to provide valuable information on its pathogenesis and treatment.Methods:In this cross-sectional study, from August 2020 to June 2021, patients with AN who were admitted into Peking University Third Hospital and Peking University Sixth Hospital (n = 30) were recruited as the AN group, and healthy controls (HC) were recruited from a middle school and a university in Beijing (n = 30). Demographic data, Hamilton Depression Scale (HAMD) scores of the two groups, and length of stay of the AN group were recorded. Microbial diversity analysis of gut microbiota in stool samples from the two groups was analyzed by 16S ribosomal RNA (rRNA) gene sequencing.Results:The weight (AN vs. HC, [39.31 ± 7.90] kg vs. [56.47 ± 8.88] kg, P < 0.001) and body mass index (BMI, AN vs. HC, [14.92 ± 2.54] kg/m2vs. [20.89 ± 2.14] kg/m2, P < 0.001) of patients with AN were statistically significantly lower than those of HC, and HAMD scores in AN group were statistically significantly higher than those of HC. For alpha diversity, there were no statistically significant differences between the two groups; for beta diversity, the two groups differed obviously regarding community composition. Compared to HC, the proportion of Lachnospiraceae in patients with AN was statistically significantly higher (AN vs. HC, 40.50% vs. 31.21%, Z = –1.981, P = 0.048), while that of Ruminococcaceae was lower (AN vs. HC, 12.17% vs. 19.15%, Z = –2.728, P = 0.007); the proportion of Faecalibacterium (AN vs. HC, 3.97% vs. 9.40%, Z = –3.638, P < 0.001) and Subdoligranulum (AN vs. HC, 4.60% vs. 7.02%, Z = –2.369, P = 0.018) were statistically significantly lower, while that of Eubacterium_hallii_group was significantly higher (AN vs. HC, 7.63% vs. 3.43%, Z = –2.115, P = 0.035). Linear discriminant effect (LEfSe) analysis (LDA score >3.5) showed that o_Lachnospirales, f_Lachnospiraceae, and g_Eubacterium_hallii_group (o, f and g represents order, family and genus respectively) were enriched in patients with AN. Microbial function of nutrient transport and metabolism in AN group were more abundant (P > 0.05). In AN group, weight and BMI were significantly negatively correlated with the abundance of Bacteroidota and Bacteroides, while positively correlated with Subdoligranulum. BMI was significantly positively correlated with Firmicutes; HAMD scores were significantly negatively correlated with Faecalibacterium.Conclusions:The composition of gut microbiota in patients with AN was different from that of healthy people. Clinical indicators have correlations with the abundance of gut microbiota in patients with AN.
简介:MRIFEATURESANDRESECTABILITYPREDITIONOFESOPHAGEALCARCINOMAKongXiangquan孔祥泉Luohanchao罗汉超PengZhenjun彭振军LiuDingxi刘定西DepartmentofR...
简介:CLINICOPATHOLOGICFEATURESANDDIAGNOSISOFCOMBINEDHEPATOCELLULARANDCHOLANGIOCARCINOMALuJianping路建平;CaiWeimin蔡为民;HayashiKeiki1林肇辉...